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Title: Metabolic profile of patients with polycystic ovary syndrome depending on the phenotype

Author:

Ożga, Katarzyna Maria

Date:

2021

Type:

Praca doktorska

Abstract:

The aim of the study was to evaluate the differences in metabolic profile depending on the Rotterdam PCOS phenotype and to compare lipid profiles between the metabolic and reproductive phenotype of PCOS. The study included data from 1300 women of reproductive age, who are the patients of the Gynecological Endocrinology and Gynecology Department in the years 2010-2020. In the first part of the study, patients were divided into 4 groups according to Rotterdam PCOS phenotypes, while in the second part 2 groups were distinguished: the group with insulin resistance (IR) and the group with preserved insulin sensitivity (IS). The study showed that HDL concentration in hyperandrogenic phenotypes was significantly lower compared to phenotype D, while TG concentration was significantly higher in phenotypes A and B compared to phenotype D. Hyperandrogenic phenotypes were characterized by significantly higher fasting insulin concentration. Phenotype A had significantly higher HOMA-IR values compared to phenotype D. Significant differences in lipid profiles have been shown between patients with IR and patients with IS. There was a positive correlation between fasting insulin, insulin in OGTT and HOMA-IR with total cholesterol, LDL and TG, and negative correlation with HDL. It has also been documented that insulin resistance affects lipid levels independent of the patient's BMI.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

ginekologia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Jach, Robert

Date issued:

2020

Identifier:

oai:dl.cm-uj.krakow.pl:4690

Call number:

ZB-133528

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

polycystic ovary syndrome triglycerides LDL HDL insulin resistance

Object collections:

Last modified:

Apr 8, 2024

In our library since:

May 23, 2022

Number of object content hits:

6

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4691

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Edition name Date
ZB-133528 Apr 8, 2024

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