Title:

The analysis of dendritic cells as predictive biomarkers of responsiveness to hydroxychloroquine treatment in primary cicatricial alopecia patients

Author:

Kłosowicz, Agata

Subject:

cicatricial alopecia ; hydroxychloroquine ; dendritic cells

Abstract:

Primary cicatricial alopecia (PCA) encompasses a diverse group of inflammatory diseases characterized by the replacement of hair follicle structures by fibrous tissue. The treatment of choice for PCA patients is hydroxychloroquine (HCQ) although not all patients are equally responsive. We investigated whether dendritic cells could affect the antimalarial responsiveness, and if dendritic cells might be used as predictive factor of responsiveness to hydroxychloroquine. In this retrospective cohort study 65 PCA patients were grouped accordingly to their response to hydroxychlorochine therapy. On immunohistochemistry, we analyzed the population and distribution of Langerhans cells, plasmacytoid, myeloid and monocyte-derived dendritic cells. We have demonstrated that the number of plasmacytoid and myeloid dendritic cells as well as Langerhans cells in lesional skin of HCQ responders was higher in comparison with HCQ non-responders. We also showed that dendritic cells might be used as an additional clue in differential diagnosis of PCA. The results of this study are important as identifying biomarkers for responsiveness to a HCQ therapy will be helpful to individualize treatment, minimize the side effects and improve patient’s compliance.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

dermatologia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Wojas-Pelc, Anna

Date:

2022

Date issued:

2020

Type:

Praca doktorska

Call number:

ZB-134795

Language:

pol

Access rights:

nieograniczony