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Title: Analysis of the airway remodeling in patients with asthma-chronic obstructive pulmonary disease overlap

Author:

Górka, Karolina

Date:

2021

Type:

Praca doktorska

Abstract:

The objective of the study was to assess the structural changes of the airways using endobronchial ultrasound (EBUS) and based on histopathological analysis of endobronchial biopsies in patients with asthma-chronic obstructive pulmonary disease overlap (ACO) compared to patients with severe asthma and chronic obstructive pulmonary disease (COPD). The study included 17 patients with ACO, 17 patients with COPD and 33 patients with severe asthma who underwent spirometry, bodyplethysmography, bronchoscopy with EBUS, bronchoalveolar lavage and endobronchial biopsies. Images were chosen from the movie recorded during bronchoscopy with EBUS based on which the total thickness of the bronchial wall and its particular layers were assessed. Histopathological evaluation of endobronchial biopsies and cytological analysis of bronchoalveolar lavage fluid were performed. Patients with ACO do not have a characteristic pattern of airway remodeling in histopathological examination of endobronchial biopsies, but have more severe changes in the airways assessed by the EBUS compared to patients with COPD, and less severe compared to patients with severe asthma. The thickness of bronchial wall and its particular layers in EBUS did not correlate with the results of histopathological examination of endobronchial biopsies in patients with ACO.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia

Degree grantor:

Wydział Lekarski

Promoter:

Soja, Jerzy

Date issued:

2020

Identifier:

oai:dl.cm-uj.krakow.pl:4679

Call number:

ZB-133506

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

asthma-chronic obstructive pulmonary disease overlap bronchoscopy endobronchial ultrasound endobronchial biopsy airway remodeling

Object collections:

Last modified:

Jul 19, 2023

In our library since:

May 23, 2022

Number of object content hits:

6

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4680

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Edition name Date
ZB-133506 Jul 19, 2023

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