Title:

Interim PET/CT response evaluation of advance Hodgkin Lymphoma (HL)

Author:

Kocurek, Anna

Subject:

Hodgkin Lymphoma ; PET/CT ; response evaluation ; interim exam ; escBEACOPP

Abstract:

In the response to treatment in Hodgkin's disease one may observe the shrinkage of the neoplastic lesions as well as normalization of 18-FDG uptake in their topography. The study examines the usefulness of various assessment methods of the PET/CT performed early after the introduction of treatment in 58 patients with advanced disease (interim), treated with a regimen starting with escBEACOPP, in case of a good response de-escalated to ABVD. The treatment regimen resulted in 88,3% OS and 83,3 % PFS after median 10,2 years of follow-up. Combination of the PET and CT criteria allowed to increase PPV while maintaining high NPV (86% and 96.1% respectively vs. 50% and 97.7% compared PET criteria alone). Additional information allowing to distinguish people with progression or recurrence of the disease were the ratio of SUV changes to liver SUV (expressed as rPET or qPET), metabolic tumour volume (MTV) in the interim PET, as well as the change of SUV between baseline and interim exams.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

hematologia

Degree grantor:

Wydział Lekarski

Promoter:

Jurczak, Wojciech

Date issued:

2020

Type:

Praca doktorska

Call number:

ZB-134101

Language:

pol

Access rights:

nieograniczony