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Title: Perioperative cardiovascular complications - the role of hemostasis in the pathogenesis of myocardial injury after noncardiac surgery (MINS) and the incidence of deep vein thrombosis after vascular surgery


Myocardial injury after non-cardiac surgery (MINS) is the most common complication after non-cardiac surgery and is associated with an increased risk of death after surgery. 475 patients were enrolled in the study and the MINS frequency was evaluated. TnT levels were determined at several time points in patients qualified for vascular surgery. 47 patients (9.9%) met the MINS criteria. A control group was then selected from 84 patients without MINS. Markers of excessive coagulation and fibrinolysis activation and inflammation were determined in the study group. Subsequently, a subgroup of 164 patients was assessed in order to access the incidence of MINS and deep vein thrombosis of the lower extremities (DVT) and their effect on prognosis one year after surgery. MINS was diagnosed in 47 patients (47/475; 9.9%). Preoperative vWF concentration and activity, factor VIII activity, fibrinogen concentration, and PAP and D-dimer concentration, but not antithrombin and tPA, were higher in patients with MINS. The frequency of MINS and DVT were then compared in a subgroup of 164 patients. In the analyzed group, 39 MINS cases (39/164, 23.8%) and 4 DVT cases (4/164, 2.4%) were found. Mortality in the MINS group was significantly higher (MINS vs. non-MINS; 23.1% vs. 7.2%). No deaths in DVT patients were observed. MINS is a significant, more common than DVT, complication after vascular surger ; y and is associated with higher mortality. The pathogenesis of MINS remains unknown, but elevated preoperative levels of markers of coagulation and fibrinolysis activation are associated with a higher risk of MINS after surgery.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

chirurgia ; choroby układu krążenia

Degree grantor:

Wydział Lekarski


Szczeklik, Wojciech

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pol; eng

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tylko w bibliotece

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Last modified:

Jul 10, 2023

In our library since:

May 23, 2022

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Edition name Date
ZB-133507 Jul 10, 2023




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