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This publication is protected and can be accessed only from certain IPs.

Title: Virulence factors of selected Gram-positive cocci causing invasive infections, especially in peri-labor women and newborns with low birth weight

Abstract:

Gram-positive cocci are described as the leading infectious agents in humans. They are responsible for a wide range of diseases about different degree of the heaviness. Some of them, although they relatively rarely appear, have invasive character i.e. are developing in physiologically barren organs and, in spite of the treatment, are burdened with the high mortality. The main aim of the study was to understand the mechanisms of virulence increasing the risk of acquiring and severe course of infections caused by certain strains of S.pyogenes and coagulasenegative staphylococci. The study material consisted of Streptococcus pyogenes strains, that were isolated from patients who developed clinical symptoms of invasive GAS infections, and of Coagulase-negative staphylococci strains, that were isolated from the blood, faeces and vascular catheters of low birth weight newborns in whom sepsis was confirmed. The studied strains of gram-positive cocci originating from invasive infections showed an increased ability to invade and survive in tissues, and a lower ability to colonize the tissue surface. The commonly functioning hypothesis of greater virulence of strains caused by the presence of numerous virulence genes has not been confirmed. It has been shown that the binding of iron ions by group A streptococci may increase their pathogenicity. Coagulase-negative staphylococci that ; colonize the intestines of premature infants with low birth weight have been shown to have the ability to translocate and induce sepsis.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Wydział Lekarski

Promoter:

Strus, Magdalena

Date issued:

2021

Identifier:

oai:dl.cm-uj.krakow.pl:4672

Call number:

ZB-134103

Language:

pol; eng

Access rights:

tylko w bibliotece

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Last modified:

Jun 30, 2022

In our library since:

May 23, 2022

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http://dl.cm-uj.krakow.pl:8080/publication/4673

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ZB-134103 Jun 30, 2022
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