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Title: Effect of a diet containing natural pre- and probiotics, DNA methylation and modification of bacterial flora for the reduction of adipose tissue

Author:

Jagielski, Paweł

Date:

2018

Type:

Praca doktorska

Abstract:

The poor quality of the diet of obese people affects the epigenetic processes and gut microbiota, which may contribute to problems with weight reduction. The main aim of this thesis was to evaluate the effectiveness in the reduction of fat mass by low-energy diet enriched potential pre-and probiotics compared to the standard reduction diet. The study subjects obese women with simple obesity, aged 25-45 years. Diet intervention lasted for three months, during which women with Diet B used the standard low-calorie diet while women with Diet A used low-calorie diet with increased frequency of eating potential pre- and probiotics. After three months the average reduction of adiposetissue was 5.63±3.10 kg regardless of the diet used. In the stool samples of both studied groups there was an increase in the number of Akkermansia muciniphila bacteria and reducing the Faecalibacterium prausnitzii bacterias in group women using the standard diet. The level of global DNA methylation did not change after 3 months of diet, however, a positive correlation between fat mass and the global level of methylation was noted depending on the quality of used diet. A potential possibility of regulating the methylation regulation of FTO gene promoter with diet was observed.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Wydział Lekarski

Promoter:

Wybrańska, Iwona

Date issued:

2018

Identifier:

oai:dl.cm-uj.krakow.pl:4643

Call number:

ZB-130751

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

obesity eating behaviour probiotics gut microbiota DNA methylation

Object collections:

Last modified:

Feb 27, 2023

In our library since:

May 5, 2022

Number of object content hits:

0

Number of object content views in PDF format

1

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4644

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Edition name Date
ZB-130751 Feb 27, 2023

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