Structure and biological activity of steroidal glycosides isolated from ramson Allium ursinum L - Digital Medical Library

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Title: Structure and biological activity of steroidal glycosides isolated from ramson Allium ursinum L

Author:

Sobolewska, Danuta

Date:

Type:

Praca doktorska

Abstract:

Two steroidal saponins: (25R,S)- spirost-5-en-3β-ol tetrasaccharide and its furostanol protoglycoside, along with a 3-hydroxy-pregna-5,16-dien-20-on glycoside were isolated from the underground parts of ramson Allium ursinum L. - a representative from the Alliaceae native to Poland. The structures of the isolated compounds were established based upon chromatographic methods and ID- and 2DNMR, MS and IR analyses. The spirostanol saponin exhibited a remarkable activity in vitro against cancer cell lines melanoma B16 and sarcoma XC (ED50 < 1 μg/ml), while its cytotoxicity against human fibroblasts was significantly lower. The compound had only weak fungistatic effect on dermatophytes (Trichophyton mentagrophytes and Microsporum can is) and yeasts (Candida glabrata and Candida parapsilosis). The furostanol protoglycoside and the pregnadienolone glycoside exhibited weaker effects against melanoma B16 than the spirostanol saponin.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Janeczko, Zbigniew

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4642

Call number:

Language:

Access rights:

tylko w bibliotece

Subject and keywords:

Allium ursinum steroidal saponins cytotoxicity antimicrobial activity

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Jan 30, 2023

In our library since:

Apr 29, 2022

Number of object content hits:

5

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4643

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Edition name	Date
ZB-100269	Jan 30, 2023

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