Title:

The impact of syncope in patients with vasovagal syncope on the central nervous system and neurocognitive functions

Author:

Jędrzejczyk-Spaho, Joanna

Subject:

vasovagal syncope ; neurocognitive functions ; specific neuronal enolase ; protein S-100

Abstract:

Introduction: Reflex syncope is the most common cause of syncope in all age groups. Aim: To assess the impact of syncope in patients with vaso-vagal syncope on the central nervous system and neurocognitive functions. Materials and methods: 42 people with a history of syncope/presyncope, qualified for the head-up tilt test (HUTT). Control group - 30 people with no history of syncope/presyncope. In the study group, plasma concentrations of specific neuronal enolase (NSE) and protein S-100 were measured before and 2 hours after HUTT. Patients both in the study and control group performed a battery of neuropsychological tests: COG, CORSI, DAUF. Results: No statistically significant increase in NSE or S-100 protein 2 hours after HUTT. Positive correlation between the duration of hypotension (SBP <70 mmHg) during syncope and the increase in NSE after HUTT. The hypotension > 60 seconds is an independent risk factor for the increase in NSE after HUTT. Study group scored worse in the DAUF test (deterioration in attention and concentration). Patients with an increase in NSE after HUTT scored worse in all performer neuropsychological tests (COG, CORSI, DAUF). Conclusions: The risk of CNS microdamage is higher when hypotension accompanying syncope is > 60 seconds. An increase in NSE during HUTT-induced syncope may identify patients at risk of worsening of neurocognitive functions.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Wydział Lekarski

Promoter:

Nessler, Jadwiga ; Pietrucha, Artur

Date:

2022

Date issued:

2021

Type:

Praca doktorska

Call number:

ZB-134969

Language:

pol

Access rights:

nieograniczony

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