Obiekt
Tytuł: The role of selected serum miRNAs and the carotid intima-media thickness complex in immediate and long-term prognosis after myocardial infarction
Abstrakt:
The main goal of the study was to identify diagnostic and prognostic markers in patients with acute coronary syndrome (ACS), with special focus on microRNAs (miRs) and carotid intima-media complex (CIMT) changes 215 patients with ACS and 71 with recent cerebral ischemic event (CIE) were enrolled. In randomly selected 43 ACS patients, miR levels were analysed. The achieved results lead to the following conclusions: Expression of miRs in ACS is associated with the risk of infarct-related coronary artery occlusion and promotes urgent coronary angiography. In ACS and CIE patients, similar miR-1-3p, miR-133a-3p and miR-133b are observed, which suggests a common mechanism of ischemia. Whereas, higher levels of miR-16-5p and miR-122-5p were observed in CIE, while miR-124-3p, miR-134-5p, miR-34a-5p, miR-208b-3p and miR-499-5p in ACS. The risk of adverse major cardiovascular events (MACCE) was associated with expression of miR-208b, miR-133b, miR-499 and miR-34a. Serial CIMT changes was identified as an important prognostic marker of MACCE. As little as, the annual CIMT increase >0.003 mm/y was associated with increased risk of MACCE, recurrent ACS and angina de novo (sensitivity: 80-84.5%, specificity: 47-49.3%). Despite, administration of the therapy following ACS, the regression of carotid atherosclerosis is found in less than 1/3 of subjects. Obtaining CIMT reduction confirms th ; e treatment efficacy, whereas CIMT progression should be associated with an intensification of the therapeutic modalities.
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Data ostatniej modyfikacji:
26 cze 2023
Data dodania obiektu:
5 kwi 2022
Liczba wyświetleń treści obiektu:
86
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103
Wszystkie dostępne wersje tego obiektu:
http://dl.cm-uj.krakow.pl:8080/publication/4631
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| Nazwa wydania | Data |
|---|---|
| ZB-130566 | 26 cze 2023 |
Obiekty
Podobne
Gacoń, Jacek
Pawliński, Łukasz
Płatek, Teresa
Świrta, Jarosław Szymon
Plicner, Dariusz
