Title:

The role of selected serum miRNAs and the carotid intima-media thickness complex in immediate and long-term prognosis after myocardial infarction

Author:

Gacoń, Jacek

Subject:

acute coronary syndrome ; changes in carotid intima-media complex (CIMT) ; microRNAs ; diagnostic and prognostic markers ; cardiovascular events

Abstract:

The main goal of the study was to identify diagnostic and prognostic markers in patients with acute coronary syndrome (ACS), with special focus on microRNAs (miRs) and carotid intima-media complex (CIMT) changes 215 patients with ACS and 71 with recent cerebral ischemic event (CIE) were enrolled. In randomly selected 43 ACS patients, miR levels were analysed. The achieved results lead to the following conclusions: Expression of miRs in ACS is associated with the risk of infarct-related coronary artery occlusion and promotes urgent coronary angiography. In ACS and CIE patients, similar miR-1-3p, miR-133a-3p and miR-133b are observed, which suggests a common mechanism of ischemia. Whereas, higher levels of miR-16-5p and miR-122-5p were observed in CIE, while miR-124-3p, miR-134-5p, miR-34a-5p, miR-208b-3p and miR-499-5p in ACS. The risk of adverse major cardiovascular events (MACCE) was associated with expression of miR-208b, miR-133b, miR-499 and miR-34a. Serial CIMT changes was identified as an important prognostic marker of MACCE. As little as, the annual CIMT increase >0.003 mm/y was associated with increased risk of MACCE, recurrent ACS and angina de novo (sensitivity: 80-84.5%, specificity: 47-49.3%). Despite, administration of the therapy following ACS, the regression of carotid atherosclerosis is found in less than 1/3 of subjects. Obtaining CIMT reduction confirms th ; e treatment efficacy, whereas CIMT progression should be associated with an intensification of the therapeutic modalities.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Wydział Lekarski

Promoter:

Kabłak-Ziembicka, Anna

Date:

2019

Date issued:

2019

Type:

Praca doktorska

Call number:

ZB-130566

Language:

pol; eng

Access rights:

nieograniczony

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