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This publication is protected and can be accessed only from certain IPs.

Title: New diagnostic possibilities and impact of chronic aspirin treatment on biomarkers in patients with nonsteroidal anti-inflammatory drugs exacerbated respiratory disease

Author:

Tyrak, Katarzyna

Date:

2020

Type:

Praca doktorska

Abstract:

Chronic aspirin intake after successful desensitization is an effective and safe treatment method for patients with nonsteroidal antiinflammatory drugs exacerbated respiratory disease (N-ERD). Aspirin provocation test remains a reliable diagnostic method of aspirin hypersensitivity. Objectives: 1. The assessment of the impact of chronic aspirin therapy on selected clinical, biochemical and radiological factors in patients with N-ERD. 2. An attempt to create an artificial neural network (ANN) that would allow a noninvasive and rapid diagnosis of N-ERD. It was shown that chronic aspirin intake leads to a decrease in periostin concentration and eosinophil count in induced sputum. It was also demonstrated that chronic aspirin intake does not affect the levels of pro- and anti-inflammatory eicosanoids produced locally (ie, in induced sputum supernatant and nasal lavage) and systemically (ie, in urine). The ANN can be used to predict the diagnosis of N-ERD in patients with asthma. The sensitivity of the ANN for the prediction of N-ERD was 94% and the specificity was 73%.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

pulmonologia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Mastalerz, Lucyna

Date issued:

2020

Identifier:

oai:dl.cm-uj.krakow.pl:4626

Call number:

ZB-132346

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

nonsteroidal anti-inflammatory drugs exacerbated respiratory disease chronic aspirin treatment induced sputum nasal lavage artificial neural network

Object collections:

Last modified:

Apr 8, 2024

In our library since:

Apr 5, 2022

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0

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4627

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Edition name Date
ZB-132346 Apr 8, 2024

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