Evaluation of molecular mechanisms of action of negative pressure wound therapy in the treatment of neuropathic ulcers in diabetic foot syndrome - Digital Medical Library

Skip to main menu
Skip to search engine
Skip to content
Skip to footer

Download

This publication is protected and can be accessed only from certain IPs.

This publication is protected and can be accessed only from certain IPs.

Description
Information

Title: Evaluation of molecular mechanisms of action of negative pressure wound therapy in the treatment of neuropathic ulcers in diabetic foot syndrome

Author:

Borys, Sebastian

Date:

Type:

Praca doktorska

Abstract:

Diabetic foot syndrome is frequently occurring together with ulceration (DFU). Negative pressure wound therapy (NPWT) is adjuvant method in DFU treatment. NPWT molecular mechanism of action is not fully understood. The objective of this doctoral thesis was evaluation of selected aspects of clinical use and molecular mechanisms of action of NPWT in type 2 diabetes mellitus (T2DM) patients with DFU. The assignment to NWPT was non-randomized and based on wound characteristics, clinical guidelines and local clinical practice. Groups were similar in clinical characteristics. The NPWT group had greater wound area. The study proved that NPWT is not more effective than standard therapy, however, due the greater DFU area, one may hypothesizes that NPWT is more effective. Interestingly, the rate of ulcer recurrence was almost the same in both groups, in spite of a large difference in the magnitude of their initial area. The effect of NPWT in DFS may be mediated through differential gene expression of proteins involved in inflammatory process and through alterations of DNA methylation resulting mainly in inhibition of the complement system activation. These findings may be of value in guiding the development of new therapies for DFUs. However, it requires further confirmation in subsequent studies.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Kieć-Wilk, Beata

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4621

Call number:

Language:

Access rights:

tylko w bibliotece

Subject and keywords:

diabetic foot syndrome diabetic foot ulceration negative pressure wound therapy wound healing

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Apr 8, 2024

In our library since:

Apr 5, 2022

Number of object content hits:

12

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4622

Show description in RDF format:

Show description in OAI-PMH format:

Edition name	Date
ZB-132338	Apr 8, 2024

Objects

Similar

Evaluation of molecular mechanisms of action of negative pressure wound therapy in the treatment of neuropathic ulcers in diabetic foot syndrome

Borys, Sebastian

2020

Praca doktorska

The influence of Integra DRT on inflammation and growth factorslevels during wound healing in experimental and clinical study

Nessler, Michał

2013

Praca doktorska

Angiogenesis in ischemic diabetic foot syndrome in patients after endovascular revascularization of lower limb arteries

Schönborn, Martyna

2025

Praca doktorska

Analysis of the microcirculation in the process of woundhealing after surgical treatment of stomatitis protheticahyperplastica fibrosa

Ryniewicz, Joanna

2014

Praca doktorska

Leczenie Ran

e-czasopismo

Rola opatrunków podciśnieniowych w leczeniu ran po relaparotomiach

Kowalewski, Maciej

2019

Praca doktorska

More

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

https://bm.cm.uj.edu.pl/en/main-page/

This page uses 'cookies'. More information