Title:

New non-pharmacological treatment methods in heart failure

Author:

Drożdż, Tomasz

Subject:

chronic heart failure ; slow breathing training ; cardiac resynchronization therapy ; renal denervation

Abstract:

The aim of the study was to evaluate the safety and influence of: a) slow breathing training (SBT); b) renal denervation (RDN); on physical capacity, haemodynamic parameters and quality of life in patients with heart failure with reduced left ventricular ejection fraction (HFrEF). RESPeRATE devices were used for SBT. 96 patients completed alternating 10-12 weeks phases of SBT and standard therapy. Patients were assessed for their clinical condition, respiratory disturbances, physical capacity, heart function and laboratory tests. SBT was safe, did not cause hypotension. SBT increased exercise capacity and systolic function of the left ventricle, and reduced the number of respiratory disorders during sleep. The results show that SBT may be a new method of non-pharmacological treatment of heart failure. For the second part of the study 20 patients with symptomatic HFrEF despite resynchronization therapy were enrolled and randomly assigned to renal artery ablation (RDN) and control groups. Autonomic system assessment, echocardiography, quality of life assessment using the Minnesota questionnaire, 6-minute walk test, kidney function and selected biochemical tests (NT-proBNP) were performed. RDN was safe, but in symptomatic, despite resynchronization, patients it did not lead to any significant improvement in the most important parameters assessing the severity of HFrEF.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Wydział Lekarski

Promoter:

Czarnecka, Danuta

Date:

2021

Date issued:

2020

Type:

Praca doktorska

Call number:

ZB-133858

Language:

pol; eng

Access rights:

nieograniczony