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This publication is protected and can be accessed only from certain IPs.

Title: Effectiveness as a key element of health technology assessment reports : pragmatic clinical trials

Author:

Kaczyński, Łukasz

Date:

2022

Type:

Praca doktorska

Abstract:

The aim of this dissertation was to systematize information on pRCTs and the development of a tool for assessing the quality of trials without randomization. This information obtained by systematic reviews in medical databases (PubMed, EmBase and Cochrane). Pragmatic clinical trials have been shown to be a valuable and reliable source of information, and several tools have been provided for assessment their quality, including the PRECIS-2. Critical evaluation of the questionnaires for quality assessment of observational studies was done. An own 19-point questionnaire for assessing the quality of non-randomized trials (SQAROS) was developed, in which attempts were made to answer the shortcomings of the found questionnaires. Using found/developed scales, a model evaluation of olanzapine compared to aripiprazole effect in patients with schizophrenia experiencing agitation was performed. All presented results indicate that due to the utility of PRECIS-2 and SQAROS (which requires further validation), the widespread use of such a tools is necessary for assessment of practical effectiveness.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

zdrowie publiczne

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Solnica, Bogdan

Date issued:

2021

Identifier:

oai:dl.cm-uj.krakow.pl:4598

Call number:

ZB-134587

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

pragmatic randomized controlled trials (pRCTs) health technology assessment (HTA) quality assessment PRECIS-2 SQAROS

Object collections:

Last modified:

Apr 8, 2024

In our library since:

Mar 31, 2022

Number of object content hits:

5

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4599

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Edition name Date
ZB-134587 Apr 8, 2024

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