New 2-aminoimidazolone derivatives as adjuvants able to inhibit mechanisms of bacterial and cancer multidrug resistance - Digital Medical Library

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Title: New 2-aminoimidazolone derivatives as adjuvants able to inhibit mechanisms of bacterial and cancer multidrug resistance

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Praca doktorska

Abstract:

Multidrug resistance (MDR) is a global problem in the treatment of bacterial infections and cancer. One of the solutions is to search for adjuvants able to block at least one of the mechanisms of resistance. Research performed within this PhD-thesis included design, synthesis, biological as well as “drug-like” properties evaluation of the 2-aminoimidazolone derivatives as potential adjuvants in the treatment of bacterial infections and cancer. Design of new compounds was conducted on the basis of previously found active compounds. A series of 49 new imidazolones was synthesized in 3-6- stages. The obtained compounds were tested for their antibiotic adjuvant activity in Gram positive and Gram negative bacterial strains, while determination of their adjuvant activity in chemotherapy was performed in T-lymphoma cancer cells. An attempt to assess mechanisms of imidazolones` action was taken using both, in silico and in vitro assays. For selected imidazolones, ADMETox and physicochemical assays were carried out. Finally, structureactivity relationship (SAR) studies were conducted. This research indicated that 2-aminoimidazolones displayed potency of adjuvants for the treatment of multidrug resistant bacterial infections and cancer.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Rada Dyscypliny Nauki farmaceutyczne

Promoter:

Handzlik, Jadwiga

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4596

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tylko w bibliotece

Subject and keywords:

imidazolones adjuvants MDR bacteria cancer

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Apr 11, 2024

In our library since:

Mar 31, 2022

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http://dl.cm-uj.krakow.pl:8080/publication/4597

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Edition name	Date
ZB-134219	Apr 11, 2024

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