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Kaczor, Aneta
2021
Praca doktorska
Multidrug resistance (MDR) is a global problem in the treatment of bacterial infections and cancer. One of the solutions is to search for adjuvants able to block at least one of the mechanisms of resistance. Research performed within this PhD-thesis included design, synthesis, biological as well as “drug-like” properties evaluation of the 2-aminoimidazolone derivatives as potential adjuvants in the treatment of bacterial infections and cancer. Design of new compounds was conducted on the basis of previously found active compounds. A series of 49 new imidazolones was synthesized in 3-6- stages. The obtained compounds were tested for their antibiotic adjuvant activity in Gram positive and Gram negative bacterial strains, while determination of their adjuvant activity in chemotherapy was performed in T-lymphoma cancer cells. An attempt to assess mechanisms of imidazolones` action was taken using both, in silico and in vitro assays. For selected imidazolones, ADMETox and physicochemical assays were carried out. Finally, structureactivity relationship (SAR) studies were conducted. This research indicated that 2-aminoimidazolones displayed potency of adjuvants for the treatment of multidrug resistant bacterial infections and cancer.
Kraków
2 - studia doktoranckie
Wydział Farmaceutyczny
Handzlik, Jadwiga
oai:dl.cm-uj.krakow.pl:4596
ZB-134219
pol; eng
tylko w bibliotece
May 23, 2022
Mar 31, 2022
0
http://dl.cm-uj.krakow.pl:8080/publication/4597
RDF
OAI-PMH
Gonet-Surówka, Agnieszka
Gosiewski, Tomasz
Otrębska-Machaj, Ewa
Witek, Karolina
Marć, Małgorzata Anna
Citation style: chicago-author-date iso690-author-date
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