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Title: Analysis of prognostic factors in children with neuroblastoma
Abstract:
Neuroblastoma (NB) is the most common malignancy in infants. The etiology remains unknown. The tumor is most often located in the abdominal cavity. Known prognostic factors include: patient's age, stage of completion, and NMYC amplification. Most children with NB have an aggressive disease with OS around 30%. Neuroblastic tumors are characterized by clinical, histological and genetic heterogeneity. The aim of the study was to assess known and search for new prognostic factors in children with NB. In the group of 180 children, the majority were over 1 year of age. 45% of patients were diagnosed with stage 4 disease. Metastasis was observed in 95 children. MYCN amplification was found in 25 patients. The methods of therapy were adjusted to the risk groups. 58 patients died in the study group, 42 were recurrent, 59 were 5 years old, 5-year EFS 59%. Based on statistical analyzes, it was found that the blood group of NB patients is prognostic. Blood group A Rh negative is associated with good prognosis, blood group AB Rh negative with poor prognosis. High variability of human blood group systems can have a potential effect on health and disease and the response to treatment obtained not only in patients with NB. It has been shown that leukopenia, anemia and WHO grade 3 or 4 thrombocytopenia after chemotherapy were associated with poor prognosis. The analysis of clinical, histologica ; l and biological features in children with NB allowed to indicate new, potentially significant prognostic factors that may affect the change of patients' qualification to risk groups and the choice of treatment.
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Last modified:
Apr 8, 2024
In our library since:
Mar 29, 2022
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8
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http://dl.cm-uj.krakow.pl:8080/publication/4574
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| Edition name | Date |
|---|---|
| ZB-133510 | Apr 8, 2024 |
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