Object
Title: Genotyping and drug resistance of Staphylococcus aureus strains isolated from healthcare- and community-acquired infections in selected patient groups in southern Poland
Abstract:
The objective of the study is a descriptive epidemiological analysis of infections caused by SA considering the risk of invasive and local infections, supplemented by detailed characteristics of isolates, their virulence and drug resistance. The study encompassed adult patients of single- and multi-profile hospitals and outpatients in the Małopolska and Śląsk provinces; strains were banked in 2013. Epidemiological analyses were conducted with the help of microbial prevalence and drug resistance testing was carried out using phenotypic and genotypic methods. The presence of selected virulence genes was determined by the genotypic method. In total, 120 strains with the MRSA phenotype were isolated from various types of infection. They were subjected to genotyping using pulse electrophoresis PFGE and spa-typing. The results of the study found the prevalence of MRSA at a higher level than expected, was 15% and varied depending on where the infection was treated, its clinical form and the age of the patients. In geriatric patients, there was a significant and above-average risk of infection with highly drug-resistant strains, also in relation to antibiotics commonly employed in empirical treatment of infections, i.e. aminoglycosides and fluoroquinolones, and trimethoprim/sulfamethoxazole. The observed virulence of the strains corresponded to the one described in the literature and ; was not associated with the phenotype of the strains. The great variety of genotypes indicates a strong penetration of the non-hospital and hospital environments.
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Rada Dyscypliny Nauki medyczne
Promoter:
Wójkowska-Mach, Jadwiga ; Różańska, Anna
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Last modified:
Apr 8, 2024
In our library since:
Mar 28, 2022
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0
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http://dl.cm-uj.krakow.pl:8080/publication/4565
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| Edition name | Date |
|---|---|
| ZB-133832 | Apr 8, 2024 |
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