Psychopathological symptoms among people with epilepsy are often not recognized or treated early enough. Therefore, the study had two general objectives. First, to compare people with epilepsy, including those with well-controlled and drug-resistant epilepsy, and a control group in terms of psychological and psychophysiological variables. Secondly, to investigate the relationships between these variables. Standardized psychological questionnaires and the MindLAB Set device for measuring electrodermal activity were used. Adults diagnosed with epilepsy (117, including 48 with drug-resistant epilepsy) and 97 people from the general population, without epilepsy, were examined. People with epilepsy scored significantly higher than the control group on insecure attachment styles, depressive symptoms, anxiety, tense arousal, immature and neurotic defense mechanisms, alexithymia, and emotion control. Besides, people with epilepsy obtained lower scores in cognitive functioning, hedonistic tone, energetic arousal, and in changes of electrodermal activity, compared to the control group. People with drug-resistant epilepsy scored higher on anxiety and alexithymia than those with well-controlled seizures. The significant relationships of attachment styles with mechanisms that regulate emotions, as well as with mood, depression, and anxiety symptoms were moderated by sex and age. Atta ; chment styles in the mediation model explained almost twice as much of variance of depressive symptoms, anxiety, anger, hedonistic tone, tension, and energy arousal than in the model without mediators.