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Title: Studies of a mouse model of delayed-type hypersensitivity to casein with a test of antigen-specific immunosuppression

Author:

Wąsik, Magdalena Natalia

Date:

2022

Type:

Praca doktorska

Abstract:

Cow's milk is one of the most common causes of food allergies among children, and caseins constitute 80% of its proteins. There is a group of patients in whom allergic reaction to cow's milk is delayed, possibly cell-mediated. Recent discoveries have shown that excessive cellular response can be inhibited using specific suppressive exosomes with miRNA-150. The aim of the research was to describe the mechanism of delayed-type hypersensitivity (DTH) reaction to casein in mice and to evaluate the potential therapeutic application of casein-specific suppressive exosomes. In the present study, it was shown that DTH reaction to casein in mice is mediated by CD4 + Th1 lymphocytes and macrophages. The suppressive properties of casein-specific exosomes were confirmed in adoptive transfer in vitro and in a mouse model of DTH to casein in vivo. The strongest suppression effect was obtained with the oral route of exosomes administration. doktorat

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

immunologia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Bryniarski, Krzysztof

Date issued:

2021

Identifier:

oai:dl.cm-uj.krakow.pl:4559

Call number:

ZB-134872

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

casein delayed-type hypersensitivity cow’s milk exosomes miRNA-150

Object collections:

Last modified:

Mar 25, 2024

In our library since:

Mar 18, 2022

Number of object content hits:

6

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4560

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Edition name Date
ZB-134872 Mar 25, 2024

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