Object
Title: Analysis of neurophysiological parameters, as well as mood and cognitive function disorders accompanying the progression of limb impairment in patients with amyotrophic lateral sclerosis
Abstract:
Amyotrophic lateral sclerosis (ALS) is a progressive, incurable, multiple system neurodegenerative disease affecting upper and lower motor neurones. This PhD dissertation presents an evaluation of conduction parameters in peripheral neurones, electromyographic characteristics, as well as mood and cognitive function disorders accompanying the progression of limb impairment in ALS patients. Twenty subjects were enrolled in the study, assigned to two groups, with clinically confirmed or suspected ALS diagnosis, without comorbidities that could affect limb function. The studies showed that the compound muscle action potential (CMAP) and the minimal F wave latency are the most useful electroneurographic parameters for early diagnosis and disease monitoring, while the duration of individual motor unit potentials (MUP) is the most useful of electromyographic parameters. A gradual reduction in CMAP amplitude was found, accompanied by the prolonged minimal F wave latency and MUP duration. The progression of limb impairment was a clinical manifestation of these disorders, and this was confirmed by increasingly poorer clinical test results. The limb impairment was accompanied by cognitive impairment, with a tendency to progression over time. The depressive disorders were transiently deteriorated. The patients with limb-onset ALS had poorer motor conduction parameters and poorer limb fun ; ction when compared to patients with bulbar-onset ALS, with a simultaneous less intense progress of changes over time.
Place of publishing:
Level of degree:
Degree discipline:
Degree grantor:
Rada Dyscypliny Nauki medyczne
Promoter:
Date issued:
Identifier:
Call number:
Language:
Access rights:
Object collections:
Last modified:
Apr 8, 2024
In our library since:
Feb 8, 2022
Number of object content hits:
11
Number of object content views in PDF format
0
All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/4496
Show description in RDF format:
Show description in OAI-PMH format:
| Edition name | Date |
|---|---|
| ZB-132299 | Apr 8, 2024 |
Objects
Similar
Hübner, Ilona
Żur-Wyrozumska, Kamila
Ostrowska, Monika
Golenia, Aleksandra
Zawiślak, Dorota
Pieczyrak-Brhel, Urszula
Kijowska, Violetta
Kułaga, Agnieszka
