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This publication is protected and can be accessed only from certain IPs.

Title: Analysis of neurophysiological parameters, as well as mood and cognitive function disorders accompanying the progression of limb impairment in patients with amyotrophic lateral sclerosis

Abstract:

Amyotrophic lateral sclerosis (ALS) is a progressive, incurable, multiple system neurodegenerative disease affecting upper and lower motor neurones. This PhD dissertation presents an evaluation of conduction parameters in peripheral neurones, electromyographic characteristics, as well as mood and cognitive function disorders accompanying the progression of limb impairment in ALS patients. Twenty subjects were enrolled in the study, assigned to two groups, with clinically confirmed or suspected ALS diagnosis, without comorbidities that could affect limb function. The studies showed that the compound muscle action potential (CMAP) and the minimal F wave latency are the most useful electroneurographic parameters for early diagnosis and disease monitoring, while the duration of individual motor unit potentials (MUP) is the most useful of electromyographic parameters. A gradual reduction in CMAP amplitude was found, accompanied by the prolonged minimal F wave latency and MUP duration. The progression of limb impairment was a clinical manifestation of these disorders, and this was confirmed by increasingly poorer clinical test results. The limb impairment was accompanied by cognitive impairment, with a tendency to progression over time. The depressive disorders were transiently deteriorated. The patients with limb-onset ALS had poorer motor conduction parameters and poorer limb fun ; ction when compared to patients with bulbar-onset ALS, with a simultaneous less intense progress of changes over time.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia

Degree grantor:

Wydział Lekarski

Promoter:

Kroczka, Sławomir

Date issued:

2019

Identifier:

oai:dl.cm-uj.krakow.pl:4495

Call number:

ZB-132299

Language:

pol; eng

Access rights:

tylko w bibliotece

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Last modified:

Jun 26, 2023

In our library since:

Feb 8, 2022

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All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4496

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Edition name Date
ZB-132299 Jun 26, 2023

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