Some aspects of toxic effects of benzophenone derivative (BP-2) - Digital Medical Library

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Title: Some aspects of toxic effects of benzophenone derivative (BP-2)

Author:

Broniowska, Żaneta

Date:

Type:

Praca doktorska

Abstract:

In this study, the subject of research was a chemical UV filter, 2,2', 4,4'-tetrahydroxybenzophenone (benzophenone-2; BP-2), belonging to the group of endocrine disrupting compounds (Endocrine Disruptor Chemicals; EDC). The aim of the study was to determine the effect of BP-2 on the survival of nerve cells, immune system activity, haematological parameters and testicular function. BP-2 was administered dermally (the main route of exposure to this compound in humans) to adult male Wistar rats for a period of 4 weeks. Studies have shown that BP-2 crosses the blood-brain barrier but reaches relatively low levels in the brain. In contrast to in vitro studies, in vivo studies did not show BP-2 neurotoxic activity in adult animals. The test compound increased the activity of the immune system, provoked hyperthyroidism, and disrupted sex hormone secretion and spermatogenesis. Results obtained in this study show for the first time the effect of benzophenone-2 on the central nervous system, the immune system and blood count (no change), and confirmed the adverse effect of this compound on testicular function.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Rada Dyscypliny Nauki farmaceutyczne

Promoter:

Budziszewska, Bogusława

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4483

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Language:

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Subject and keywords:

benzophenone-2 spermatogenesis neurotoxicity hyperthyroidism immunology

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Mar 25, 2024

In our library since:

Feb 7, 2022

Number of object content hits:

186

Number of object content views in PDF format

130

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4484

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Edition name	Date
ZB-132516	Mar 25, 2024

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