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Title: Searching for new possibilities of the pharmacotherapy of posttraumatic stress disorder
Abstract:
This study aimed to indicate drugs that alter mouse behavior corresponding to symptoms of posttraumatic stress disorder (PTSD). Single prolonged stress procedure in CD-1 mice (mSPS) induced the PTSD-like phenotype. Effects of drugs were studied in the fear conditioning test (FC), forced swim test (FST), and elevated plus maze test (EPM). The impact of selected drugs on ultrasonic vocalizations was assessed. The most potent drugs were chosen and studied in female mice. Their effects on serum levels of corticosterone, estradiol, and testosterone were examined. In a PTSD-like model, in FST, the following drugs presented an antidepressant-like effect: venlafaxine, bupropion, ketamine, tiagabine, pramipexole, rotigotine, and LY341495. Bupropion, tiagabine, buspirone, LY341495, and LY354740 demonstrated anxiolytic-like effect, while buspirone, rotigotine, pramipexole, and LY341495 reduced freezing response in FC. The effect of pramipexole in FC was sex-independent, yet tiagabine was active in females only, and both differentially affected serum levels of studied hormones. The results indicate that regarding new pharmacological approaches in PTSD, the potential usefulness of dopaminergic D2-like receptor agonists and GABA reuptake inhibitors should be considered. This study suggests that the therapeutical efficacy of some medications may differ in males and fe ; males.
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Rada Dyscypliny Nauki farmaceutyczne
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Last modified:
Apr 8, 2024
In our library since:
Feb 2, 2022
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5
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0
All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/4474
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| Edition name | Date |
|---|---|
| ZB-132526 | Apr 8, 2024 |
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