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Title: Role of technetium99m-hexamethylpropyleneamine oxime-labeled white blood cell (99mTc-HMPAO-WBC) scintigraphy in the diagnosis of infective endocarditis

Author:

Holcman, Katarzyna Rita

Date:

2021

Type:

Praca doktorska

Abstract:

Infective endocarditis (IE) is a life-threatening disease. The hybrid technique of single photon emission tomography and computed tomography with technetium99m-hexamethylpropyleneamine oxime–labeled leukocytes (99mTc-HMPAO-SPECT/CT) is an emerging diagnostic tool in patients with IE. Data on the potential application of this technique in IE and cardiac device-related infective endocarditis (CDRIE) assessment was still limited. Aims of this prospective study included assessment of: (1) the diagnostic performance of 99mTc-HMPAO-SPECT/CT compared with transthoracic echocardiography (TTE) in patients with suspected IE; (2) 99mTc-HMPAO-SPECT/CT diagnostic profile and its added value to the modified Duke criteria (mDuke) in CDRIE diagnostic work-up; (3) the prognostic value of 99mTc-HMPAO-WBC scintigraphy in the course of CDRIE. In patients with suspected IE, 99mTc-HMPAO-SPECT/CT yields a significantly higher diagnostic accuracy and specificity compared to TTE. Included into CDRIE diagnostic work-up, 99mTc-HMPAO-SPECT/CT provides high diagnostic accuracy, inclusion of 99mTc-HMPAO-SPECT/CT into mDuke criteria yields significantly higher sensitivity. In course of CDRIE positive 99mTc-HMPAO-SPECT/CT results are associated with increased rates of in-hospital mortality and complications.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Kostkiewicz, Magdalena ; Ząbek, Andrzej

Date issued:

2020

Identifier:

oai:dl.cm-uj.krakow.pl:4472

Call number:

ZB-132356

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

infective endocarditis radiolabeled leukocyte scintigraphy scintigraphy 99mTc-HMPAO-SPECT/CT HMPAO

Object collections:

Last modified:

Apr 8, 2024

In our library since:

Feb 2, 2022

Number of object content hits:

11

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4473

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Edition name Date
ZB-132356 Apr 8, 2024

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