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This publication is protected and can be accessed only from certain IPs.

Title: Assessment of biomechanical properties and migration potential of Wharton's jelly mesenchymal stem cells


Mesenchymal stem cells (MSCs) promise to be a panacea for the future. However, the use of the cells in clinical practice must be preceded by an in-depth analysis of their properties, especially to determine the mechanism by which the cells contribute to the regeneration of tissues and organs. Therefore it remains necessary to search for new answers in research on these frequently used stem cells. Measurements of cell elasticity using an atomic force microscope (AFM) present a novel approach that can help us to understand the correlation between cell structure, mechanics and function, including regulation many processes (proliferation, differentiation, motility) necessary to achieve therapeutic efficacy. The main purpose of this dissertation is to investigate how the migratory potential of WJ MSCs is related to their elasticity. For this purpose, transendothelial migration and invasion tests of proinflammatory cytokines secreted by the ischemic myocardial damage were conducted. The role of adhesion molecules in these processes was assessed, and the deformability of WJ-MSCs was determined using AFM. The results obtained and presented in this dissertation indicate the relationship between the migratory potential of WJ-MSCs and the deformability of these cells. Therefore it confirms the hypothesis that WJ-MSCs’ migratory ability depends on their elasticity, which correlates with ; the structure of the cytoskeleton and changes during the in vitro cultivation.

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Level of degree:

2 - studia doktoranckie

Degree discipline:

biochemia ; fizjologia ; kardiologia

Degree grantor:

Rada Dyscypliny Nauki medyczne


Laidler, Piotr

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tylko w bibliotece

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Last modified:

Apr 8, 2024

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Feb 1, 2022

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Edition name Date
ZB-132974 Apr 8, 2024


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