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Title: Search for compounds with potential central activity in a group of aminoalkanol and piperazine derivatives

Author:

Pańczyk-Straszak, Katarzyna

Date:

2020

Type:

Praca doktorska

Abstract:

The main aim of the work was to design and synthesize new compounds with potential anticonvulsant, analgesic in neuropathic pain, antidepressant and/or anxiolytic activity, expanding knowledge about the structure – central activity relationship in the group of aminoalkanols and piperazine derivatives, as well as about their safety and mechanism of action. The preliminary part of the study characterizes the participation of selected molecular targets in pathomechanism and therapy of central nervous system diseases, including epilepsy, neuropathic pain, depression and anxiety. As part of own research, 70 aminoalkanols or piperazine derivatives were designed and obtained by chemical synthesis, including 30 centrally active compounds. Based on the obtained results, analysis of the structure-activity relationship in vitro and/or in vivo was performed. For active compounds, analysis of the potential mechanism of action was performed. Metabolic and safety studies have also been carried out for selected compounds, the results of which are estimation of the potential risk of adverse effects of the tested compounds. Selected active compounds can become a starting point in the design of further centrally active substances in the studied groups of compounds, taking into account the conclusions from this dissertation on SAR, safety, research methodology and desired molecular objectives.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia ; chemia

Degree grantor:

Wydział Farmaceutyczny

Promoter:

Żelaszczyk, Dorota ; Waszkielewicz, Anna

Date issued:

2020

Identifier:

oai:dl.cm-uj.krakow.pl:4455

Call number:

ZB-132527

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

synthesis aminoalkanols piperazine central activity

Object collections:

Last modified:

Jun 10, 2022

In our library since:

Jan 26, 2022

Number of object content hits:

5

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4456

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Edition name Date
ZB-132527 Jun 10, 2022

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