Metadata language
Title:
Organization of empirical antimicrobial treatment in the Interdisciplinary Intensive Care Unit
Author:
Subject:
empirical antibiotic therapy ; microbiological maps ; rational antibiotic therapy ; Intensive Care Unit ; drug resistance
Abstract:
Challenges of empirical antibiotic therapy in Intensive Care Units (ICUs) are widely described in the literature, however, no effective method or paradigm of empirical treatment has been developed so far. Patients admitted to ICU can have a wide variety of health conditions, history of admissions and treatment as inpatients, history of treatment as out-patients or being newly admitted. Empirical antibiotic therapy in the ICU is a necessity in most patients, and choice of antibiotics requires most careful consideration, especially in the view of increasing drug resistance. The aim of this study was to compare whether empirical antibiotic therapy based on microbiological maps is more effective than the method used previously. Analysis included data from trials conducted at Clinical Hospital of Anaesthesiology and Intensive Therapy No. 1 SU in Krakow in 2014-2015. Patients were randomly allocated in to a study group (n=50) and received empirical antibiotic therapy based on Department’s microbiological maps. Paired controls were treated with a traditional selection of empirical antibiotics. The following was included in statistical analysis: selection of drugs, results of microbiological tests, appropriateness of drug choice, duration of empirical therapy, ICU treatment duration, mortality and morbidity. This study showed that bacteriological mapping in ICU resulted in more a ; ppropriate selection of empirical antibiotic therapy (59% vs 8%) which allowed to start treatment earlier and resulted in quicker recovery. Microbiological map based empirical antibiotic therapy reduces number of hospital acquired infections in ICU, infections are treated earlier and more effectively. It has also shown to reduce duration of hospital stay in ICU and as a result treatment cost reduction.
Place of publishing:
Level of degree:
Degree discipline:
choroby zakaźne ; mikrobiologia ; anestezjologia
Degree grantor:
Rada Dyscypliny Nauki medyczne
Promoter:
Wordliczek, Jerzy ; Serednicki, Wojciech