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Title: The effect of voluntary and forced exercise on the course of experimental colitis with concomitant obesity
Abstract:
Despite the progress made in recent years, the etiology and pathogenesis of inflammatory bowel diseases (IBD), remains unclear. IBD describes a group of chronic inflammatory diseases of the gastrointestinal tract, of autoimmune origin. It is known that the obesity which is characterized, among others, by the occurrence of mesenteric white adipose tissue (mWAT) hypertrophy and creeping fat infiltrating intestinal wall, is nowadays considered as the risk factor in IBD. The aim of the study was to verify the hypothesis that obesity induced by high-fat diet in mice exacerbates the course of experimentally induced colitis and if the possible beneficial effects of exercise during colitis will affect the profile of biologically active substances. The experiments were performed on mice (C57BL/6J strain), which were fed normal diet or obesity inducing diet, and then exposed to physical exercise: voluntary in a spinning wheel or forced on a treadmill. Colitis was induced by intrarectal application of trinitrobenzenesulfonic acid. Colonic blood flow was measured and disease activity index and animal muscular strength were determined The concentration of parameters related to oxidative stress in the colon was measured: MDA+4-HNE, GSH, 8-OHdG, activity and mRNA expression of SOD-1 and SOD-2. The colonic content of pro-inflammatory cytokines IL-1β and TNF-α were also determined. It has be ; en shown that obesity exacerbates experimental colitis, and voluntary exercise accelerates the healing of colonic lesions while the forced physical activity delays the healing of this colitis.
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Rada Dyscypliny Nauki medyczne
Promoter:
Kwiecień, Sławomir ; Magierowski, Marcin
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Last modified:
Apr 8, 2024
In our library since:
Jan 21, 2022
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0
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All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/4449
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| Edition name | Date |
|---|---|
| ZB-132972 | Apr 8, 2024 |
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