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Title: Assessment of non-motor gastrointestinal symptoms and ghrelin level in Parkinson’s disease after bilateral subthalamic nucleus deep brain stimulation
Abstract:
Objective: The aim of this study was to evaluate the effect of STN-DBS on gastric motility, ghrelin plasma levels, body weight and the frequency and severity of gastrointestinal symptoms in patients with advanced PD before and after bilateral STN DBS. Subjects and methods: The study included 43 patients diagnosed with the idiopathic PD. All the patients were in advanced stage of PD, and underwent bilateral STN DBS in the Department of Neurosurgery and Neurotraumatology of the University Hospital in Krakow. Examinations were performed before and three months after bilateral STN DBS. UPDRS score as well as the Hoehn and Yahr scale were obtained to assess the neurological status and severity of PD. Gastric motility in fasting and postprandial conditions were assessed using electrogastrography (EGG). Plasma ghrelin levels were measured in the fasting state and at 30, 60, 120, and 180 min after standard meal. Frequency and severity of gastrointestinal symptoms were evaluated based on a structured gastrointestinal dysfunction questionnaire. Conclusions: STN DBS is an effective treatment for PD non-motor symptoms including gastrointestinal dysfunctions. STN DBS significantly improves gastric motility as well as gastrointestinal symptoms including constipations, difficulties in defecation and dysphagia. After STN DBS increased ghrelin concentration in preprandial and postprandial con ; dition, normalization of postprandial plasma ghrelin levels and body weight gain were observed.
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Rada Dyscypliny Nauki medyczne
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Last modified:
Apr 8, 2024
In our library since:
Jan 19, 2022
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1
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All available object's versions:
http://dl.cm-uj.krakow.pl:8080/publication/4432
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| Edition name | Date |
|---|---|
| ZB-132261 | Apr 8, 2024 |
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