Title:

Expression of estrogen and progesterone receptors in melanocytic neviand melanomas

Author:

Spałkowska, Magdalena

Subject:

nevus ; progesterone ; estrogens ; melanoma

Abstract:

In the first part of the study we assessed the expression of estrogen (α,β, GPER) and progesterone receptors in common nevi, dysplastic nevi, melanomas and healthy skin tissue margin. In the second part of the study we evaluated GPER expression in melanomas and margin tissue in men and women of different hormonal status. We have shown the presence of significant differences in estrogen β expressionin margin melanocytes between common and dysplastic nevi. Keratinocytes of melanomas and dysplastic nevi differed in estrogen receptor β expression. We did not show significant differences in estrogen α and β in relation to known prognostic factors in melanoma. Significant differences were found in estrogen β and GPER expression between margin and melanoma melanocytes. Melanocytes of melanomas and dysplastic nevi differed in GPER expression. There was a positive correlation between nuclear and cytoplasmic GPER expression in melanoma melanocytes and Clark and Breslow scales. There were differences in GPER expression in melanocytes concerning the presence of ulceration, mitotic figures and growth phase.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

dermatologia

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Wojas-Pelc, Anna

Date:

2020

Date issued:

2019

Type:

Praca doktorska

Call number:

ZB-132292

Language:

pol

Access rights:

nieograniczony