Clinical and cytogenetic prognostic factors in multiple myeloma - Digital Medical Library

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Title: Clinical and cytogenetic prognostic factors in multiple myeloma

Author:

Goldman-Mazur, Sarah

Date:

Type:

Praca doktorska

Abstract:

This monography consists of the two publications concerning theprognostic impact of translocations involving MAF(musculoaponeurotic fibrosarcoma) genes, namely translocationst(14;16) and t(14;20) in newly diagnosed multiple myeloma patients.The aim of this retrospective study was to present the clinicalcharacteristics and survival outcomes on a large group of patients withthose translocations. 254 patients with MM diagnosed betweenOctober 2005 and January 2018, testing positively for t(14;20) ort(14;16) were identified from the medical records at 29 participatinginstitutions all over the world. For t(14;16) the median PFS was 24.9months and median OS was 49.0 months; for t(14;20) median PFSwas 16.6 months and median OS was 54.0 months. In conclusion, bothtranslocations seem to have a similar implication for prognosis inaddition to their similar mechanism. The t(14;20) should beconsidered as an adverse factor of equal prognostic implication as thet(14;16) abnormality in the staging systems. Myeloma patients withMAF translocations who received double ASCT display superior OSin this retrospective dataset.

Place of publishing:

Level of degree:

2 - studia doktoranckie

Degree discipline:

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Jurczyszyn, Artur

Date issued:

Identifier:

oai:dl.cm-uj.krakow.pl:4423

Call number:

Language:

Access rights:

tylko w bibliotece

Subject and keywords:

t(14;16) translocation myeloma t(14;20) MAF

Object collections:

Digital Medical Library > PhD thesis database

Last modified:

Mar 25, 2024

In our library since:

Apr 22, 2021

Number of object content hits:

59

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4424

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Edition name	Date
ZB-132368	Mar 25, 2024

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