Title:

Clinical and cytogenetic prognostic factors in multiple myeloma

Author:

Goldman-Mazur, Sarah

Subject:

t(14;16) ; translocation ; myeloma ; t(14;20) ; MAF

Abstract:

This monography consists of the two publications concerning theprognostic impact of translocations involving MAF(musculoaponeurotic fibrosarcoma) genes, namely translocationst(14;16) and t(14;20) in newly diagnosed multiple myeloma patients.The aim of this retrospective study was to present the clinicalcharacteristics and survival outcomes on a large group of patients withthose translocations. 254 patients with MM diagnosed betweenOctober 2005 and January 2018, testing positively for t(14;20) ort(14;16) were identified from the medical records at 29 participatinginstitutions all over the world. For t(14;16) the median PFS was 24.9months and median OS was 49.0 months; for t(14;20) median PFSwas 16.6 months and median OS was 54.0 months. In conclusion, bothtranslocations seem to have a similar implication for prognosis inaddition to their similar mechanism. The t(14;20) should beconsidered as an adverse factor of equal prognostic implication as thet(14;16) abnormality in the staging systems. Myeloma patients withMAF translocations who received double ASCT display superior OSin this retrospective dataset.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

16) ; t(14

Degree grantor:

Rada Dyscypliny Nauki medyczne

Promoter:

Jurczyszyn, Artur

Date:

2020

Date issued:

2020

Type:

Praca doktorska

Call number:

ZB-132368

Language:

pol; eng

Access rights:

tylko w bibliotece