Advanced search ?

Object

Access Limited

This publication is protected and available only for logged users.
This publication is protected and available only for logged users.

Title: Relationship between NT-proBNP serum concentration and gene polymorphisms associated with NT-proBNP precursor and its receptors in patients with chronic heart failure and metabolic syndrome

Author:

Furman-Niedziejko, Anna

Date:

2020

Type:

Praca doktorska

Abstract:

Obesity is associated with a reduction of natriuretic peptides (NPs) concentration in patients with heart failure (HF). NPs levels may also be affected by components of the metabolic syndrome (MS) and single nucleotide polymorphisms (SNPs) in genes related to NPs.Purpose: Evaluation of the relation of NT-proBNP concentration with selected SNPs in patients with chronic HF and MS.Study group and methods: 88 patients with chronic HF with LVEF≤45% and MS, were divided into two groups: with obesity defined as BMI≥27kg/m2 and without obesity defined as BMI <27kg/m2. The NT-proBNP blood test, transthoracic echocardiography, body composition analysis with bioimpedance and genetic analysis of SNPs: (-381) T/C of NPPB gene, (-15129) 3C/4C of NPR1 gene and (-55) C/A of NPR3 gene were performed. The clinical observation lasted 24 months.Results: NT-proBNP concentration was negatively correlated with body weight in whole population, and with trunk lean mass in the non-obese group. The groups did not differ in respect to selected SNPs. In patients without obesity, the genotype (-381) T/C of the NPPB gene was associated with higher NT-proBNP concentration. Genotype (-15129) 3C/3C of NPR1 gene was associated with higher blood pressure , and genotype (-55) A/A of NPR3 gene was related to impaired fasting glucose and impaired glucose tolerance. Genotypes (-15129) 4C/3C and 3C/3C of NPR1 gene were associated with mixed hyperlipidaemia. There was no significant relations of SNPs or obesity to prognosis. The waist-hip ratio was an important predictor of re-hospitalization in patients with HF and MS.Conclusions: Regulation of NPs concentration is multivariate. Influence of MS components may be more important than genetic modulation. MS components may be associated with SNPs in genes related to NPs.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jadwiga Nessler

Date issued:

2019

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4420

Call number:

ZB-132291

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

heart failure metabolic syndrome obesity natriuretic peptides single nucleotide polymorphisms

Object collections:

Last modified:

Apr 21, 2021

In our library since:

Apr 21, 2021

Number of object content hits:

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4421

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-132291 Apr 21, 2021

Objects

Similar

Relationship between NT-proBNP serum concentration and gene polymorphisms associated with NT-proBNP precursor and its receptors in patients with chronic heart failure and metabolic syndrome

Furman-Niedziejko, Anna

2020
Praca doktorska

Immuno – inflammatory response, clinical outcome and early prognosis in acute myocardial infarction

Palka, Ilona

2017
Praca doktorska

Diagnostics and treatment of heart failure patients in randomly chosen outpatient clinics in Poland

Stompór, Małgorzata

2010
Praca doktorska

Polish heart failure patient population enrolled in the Long Term Heart Failure Registry and the evaluation of the patient prognosis in the 1- year follow-up

Bury, Krzysztof

Praca doktorska

The link between adiponectin gene polymorphisms and selected metabolic syndrome phenotypes

Szopa, Magdalena

2008
Praca doktorska

Response to CRT in patient with chronic heart failure depending on the ventricular leads localization

Sondej, Tomasz

2012
Praca doktorska

Effects of sildenafil in patients with fixed “venous” pulmonaryhypertension

Nowacka, Magdalena

2014
Praca doktorska

The level of: adiponectin and leptin in the blood and vessels changes in sight organ of patients with metabolic syndrome

Woś, Małgorzata

2010
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information