Obiekt
Tytuł: Evaluation of prevalence and clinical significance of low triiodothyronine syndrome and selenium deficiency in heart failure and myocardial infarction
Abstrakt:
Introduction: Both glutathione peroxidase and deiodinases are selenoproteins requiring selenium (Se). Oxidative stress accompanying myocardial infarction (MI) and heart failure (HF) may lead to activation of peroxidase, Se deficiency and impair conversion of tetraiodothyronine (T4) to triiodothyronine (T3). The aim of the study was the evaluation of the prevalence and clinical significance of low T3 syndrome in MI and HF in relation to Se deficiency. Methods: The study group: 59 patients hospitalized due to decompensation of advanced HFrEF, NYHA III or IV and 59 patients hospitalized because of MI, treated with primary coronary angioplasty. Exclusion criteria: thyroid diseases, serious systemic disease, treatment with amiodarone, steroids of propranolol. The control group: 30 asymptomatic volunteers with normal ECG. Results: The prevalence of low T3 syndrome in HF was 15.3%, in acute MI- 11.9%, in the control group – 0%. The prevalence of Se deficiency was present in 74.58% HF patients, 70.37% MI patients and in 10.0% participants of the control group. There were lowered fT3 levels and fT3/fT4 ratio in HF and MI in comparison with the control group. In MI and HF time changes of TSH and/or HT were observed. Dependence between fT3 levels, fT3/fT4 ratio and clinical parameters of myocardial injury severity in MI and parameters of heart disfunction severity in HF was documented. Th ; ere are conflicting results about dependence between Se and HT. Conclusions: It was revealed that there is relationship between low T3 syndrome and unfavorable course of HF, while no dependence between Se and unfavorable course of HF and MI was found.
Miejsce wydania:
Stopień studiów:
Dyscyplina:
Instytucja nadająca tytuł:
Promotor:
Data wydania:
Identyfikator:
Sygnatura:
Język:
Prawa dostępu:
Kolekcje, do których przypisany jest obiekt:
Data ostatniej modyfikacji:
8 kwi 2024
Data dodania obiektu:
21 kwi 2021
Liczba wyświetleń treści obiektu:
3
Liczba wyświetleń treści obiektu w formacie PDF
0
Wszystkie dostępne wersje tego obiektu:
http://dl.cm-uj.krakow.pl:8080/publication/4419
Wyświetl opis w formacie RDF:
Wyświetl opis w formacie OAI-PMH:
| Nazwa wydania | Data |
|---|---|
| ZB-132337 | 8 kwi 2024 |
Obiekty
Podobne
Frączek‑Jucha, Magdalena
Węgiel, Michał Jan
Palka, Ilona
Misztal, Marcin
Gąsior,Mariusz (oprac ).
Brzeziński, Michał
Żygadło, Agnieszka
Stompór, Małgorzata
