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Title: Evaluation of prevalence and clinical significance of low triiodothyronine syndrome and selenium deficiency in heart failure and myocardial infarction

Author:

Frączek‑Jucha, Magdalena

Date:

2020

Type:

Praca doktorska

Abstract:

Introduction: Both glutathione peroxidase and deiodinases are selenoproteins requiring selenium (Se). Oxidative stress accompanying myocardial infarction (MI) and heart failure (HF) may lead to activation of peroxidase, Se deficiency and impair conversion of tetraiodothyronine (T4) to triiodothyronine (T3). The aim of the study was the evaluation of the prevalence and clinical significance of low T3 syndrome in MI and HF in relation to Se deficiency. Methods: The study group: 59 patients hospitalized due to decompensation of advanced HFrEF, NYHA III or IV and 59 patients hospitalized because of MI, treated with primary coronary angioplasty. Exclusion criteria: thyroid diseases, serious systemic disease, treatment with amiodarone, steroids of propranolol. The control group: 30 asymptomatic volunteers with normal ECG. Results: The prevalence of low T3 syndrome in HF was 15.3%, in acute MI- 11.9%, in the control group – 0%. The prevalence of Se deficiency was present in 74.58% HF patients, 70.37% MI patients and in 10.0% participants of the control group. There were lowered fT3 levels and fT3/fT4 ratio in HF and MI in comparison with the control group. In MI and HF time changes of TSH and/or HT were observed. Dependence between fT3 levels, fT3/fT4 ratio and clinical parameters of myocardial injury severity in MI and parameters of heart disfunction severity in HF was documented. There are conflicting results about dependence between Se and HT. Conclusions: It was revealed that there is relationship between low T3 syndrome and unfavorable course of HF, while no dependence between Se and unfavorable course of HF and MI was found.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Andrzej Gackowski

Date issued:

2019

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4418

Call number:

ZB-132337

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

heart failure myocardial infarction low triiodothyronine syndrome triiodothyronine selenium

Object collections:

Last modified:

Apr 21, 2021

In our library since:

Apr 21, 2021

Number of object content hits:

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4419

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Edition name Date
ZB-132337 Apr 21, 2021

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