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Title: The association between Toll-like receptor 4-mediated inflammatory response and outcome after ischemic stroke

Author:

Klimiec-Moskal, Elżbieta

Date:

2020

Type:

Praca doktorska

Abstract:

Toll-like receptors 4 (TLR4) are pattern recognition receptors, which the main agonist is bacterial endotoxin (LPS). Expression of TLR4 on monocytes increases during ischemic stroke and correlates with poor functional outcome. Studies aimed to investigate the relationship between selected markers of immune response mediated by TLR4 and outcome after stroke. It was shown that higher level of proteins modulating the interaction between LPS and TLR4 (LBP and sCD14) is associated with higher mortality after stroke. Results suggest that decreased release of IP-10, TNFa, IL-1b and IL-12, and increased release of IL-10 and IL-8 after whole blood stimulation with LPS arerelated to poor stroke outcome. In addition, multimarker score based on IL-12, IL-10 and TNFa levels after LPS stimulation and plasmaIL-6 level improves the prognostic value of the clinical model for predicting stroke outcome.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

neurologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Tomasz Dziedzic

Date issued:

2020

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4417

Call number:

ZB-132352

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

ischemic stroke outcome inflammation endotoxin cytokines

Object collections:

Last modified:

Apr 20, 2021

In our library since:

Apr 20, 2021

Number of object content hits:

3

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4418

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Edition name Date
ZB-132352 Apr 20, 2021

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