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Title: Evaluation of selected proinflammatory cytokines in psoriatic and psoriatic arthritis patients with coexisting metabolic syndrome

Author:

Pirowska, Magdalena

Date:

2018

Type:

Praca doktorska

Abstract:

INTRODUCTION: Psoriasis is a common chronic skin disease. In recent years,research has shown the association of dermatosis with numerous accompanyingdiseases, most often with cardiovascular diseases and metabolic syndrome,determining psoriasis as a predisposing factor.OBJECTIVE: The aim of this dissertation was to evaluate the epidemiology ofpatients with psoriasis and psoriatic arthritis and to study the levels of TNF-α, IL-12,IL-23 and IL-17 in patients’ blood in correlation with individual components of themetabolic syndrome.MATERIAL AND METHODS: A retrospective study evaluated data from 3,331hospitalizations and 1,537 outpatient cards of patients with psoriasis. For the studyof cytokines 60 patients with severe psoriasis were included. Control groups were:15 subjects diagnosed with metabolic syndrome and 15 healthy voluntary subjects.The concentrations of IL-12, IL-17, IL-23 and TNF-α in serum were determined.RESULTS: The level of the studied cytokines: IL-23 and TNF-α was higher inpatients diagnosed with psoriasis in comparison to the control group. Higher levelsof IL-17 were observed in patients with metabolic syndrome associated withpsoriasis. The level of cytokines was also assessed in relation to the presence ofspecific co-morbidities that are components of the metabolic syndrome. The level ofIL-17 was higher in the group of patients diagnosed with diabetes mellitus anddislipidemia. In the study, a higher level of IL-17 and IL-23 was also shown, inpatients with psoriatic arthritis in comparison to patients with normal psoriasis.CONCLUSIONS: It seems very important to study immunologic mechanismsresponsible for the presence of psoriasis to personalize the therapy and optimize theeffect of action on the basic disease and on concomitant disorders.*

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Anna Wojas-Pelc

Date issued:

2018

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4386

Call number:

ZB-130876

Access rights:

tylko w bibliotece

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Subject and keywords:

psoriasis psoriatic arthritis metabolic syndrome proinflamatorycytokines

Object collections:

Last modified:

Oct 9, 2020

In our library since:

Oct 9, 2020

Number of object content hits:

5

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4387

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Edition name Date
ZB-130876 Oct 9, 2020

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