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Title: Evaluation of selected proinflammatory cytokines in psoriatic and psoriatic arthritis patients with coexisting metabolic syndrome


INTRODUCTION: Psoriasis is a common chronic skin disease. In recent years,research has shown the association of dermatosis with numerous accompanyingdiseases, most often with cardiovascular diseases and metabolic syndrome,determining psoriasis as a predisposing factor.OBJECTIVE: The aim of this dissertation was to evaluate the epidemiology ofpatients with psoriasis and psoriatic arthritis and to study the levels of TNF-α, IL-12,IL-23 and IL-17 in patients’ blood in correlation with individual components of themetabolic syndrome.MATERIAL AND METHODS: A retrospective study evaluated data from 3,331hospitalizations and 1,537 outpatient cards of patients with psoriasis. For the studyof cytokines 60 patients with severe psoriasis were included. Control groups were:15 subjects diagnosed with metabolic syndrome and 15 healthy voluntary subjects.The concentrations of IL-12, IL-17, IL-23 and TNF-α in serum were determined.RESULTS: The level of the studied cytokines: IL-23 and TNF-α was higher inpatients diagnosed with psoriasis in comparison to the control group. Higher levelsof IL-17 were observed in patients with metabolic syndrome associated withpsoriasis. The level of cytokines was also assessed in relation to the presence ofspecific co-morbidities that are components of the metabolic syndrome. The level ofIL-17 was higher in the group of patients diagnosed with diabetes mellitus anddislipidemia. In the study, a higher level of IL-17 and IL-23 was also shown, inpatients with psoriatic arthritis in comparison to patients with normal psoriasis.CONCLUSIONS: It seems very important to study immunologic mechanismsresponsible for the presence of psoriasis to personalize the therapy and optimize theeffect of action on the basic disease and on concomitant disorders.*

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Level of degree:

2 - studia doktoranckie

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.


Anna Wojas-Pelc

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tylko w bibliotece

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Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Oct 9, 2020

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Oct 9, 2020

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Edition name Date
ZB-130876 Oct 9, 2020


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