Acute appendicitis is the most common cause of abdominalpain requiring surgical emergency with a reported lifetime incidenceof 8%. Thus, appendectomies are among most frequent abdominalprocedures performed by general surgeons.Laparoscopic appendectomy has become the gold standard oftreatment of acute appendicitis. Therefore, further research shouldfocus on improving operative technique, identification of risk factorsof peri- and postoperative morbidity and should present outcomes inselected groups of patients (eg. elderly or patients with complicatedappendicitis). This series of publications will focus on these aspects.The aim of the study was to identify factors influencingoutcomes of laparoscopic appendectomy based on results frommulticenter cohort Pol-LA study (Polish LaparoscopicAppendectomy).Between 2017 and 2018 multicenter cohort study Pol-LA(Polish Laparoscopic Appendectomy) was conducted. It included 4618patients undergoing laparoscopic appendectomy for acute appendicitis.Results and conclusionsThe results showed that differences in clinical presentation,patients’ age and operative technique may have influence on outcomesof laparoscopic appendectomy.Identification of patients with high risk of poor clinicaloutcomes is crucial. This group includes elderly and those with riskfactors of complicated appendicitis.Outcomes of laparoscopic appendectomy differ depending onpatients’ age because the risk of complicated appendicitis increaseswith patients’ age.Closure of appendiceal stump with stapler may be associatedwith better outcomes of laparoscopic appendectomy in patients withcomplicated appendicitis.Complicated appendicitis is connected to worse outcomes oflaparoscopic appendectomy. The risk factors for this conditioninclude: female sex, age > 50 years, symptoms duration >48 h, higherAlvarado score and CRP > 100 mg/l.Postoperative intraabdominal abscess formation is associatedwith poor outcomes of laparoscopic appendectomy and complicatedappendicitis is the strongest risk factor for this complication.