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Title: The role of blood coagulation in aortic stenosis and concomitant aneurysmatiuc dilation of ascending aorta

Author:

Mazur, Piotr

Date:

2019

Type:

Praca doktorska

Abstract:

This monography consists of three publications concerning pathophysiology of degenerative aortic stenosis (AS). The research was funded by a grant from the National Science Centre (2012/05/N/NZS/00846 to Piotr Mazur). The priority was to evaluate the role of coagulation, fibrinolysis impairment, immune system involvement and genetic regulation of valvular calcification in a cohort of patients being surgical candidates. Because valvular heart disease is associated with increased thromboembolic risk, and impaired fibrinolysis was reported in severe AS, while data about fibrinolysis impairment in degenerative mitral stenosis (MS) were scarce, we first sought to compare fibrinolysis impairment in AS and MS. Then, we sought to investigate the role of different circulating lymphocyte and monocyte subpopulations, with focus on CD4+CD8+ lymphocytes and natural killer T (NKT) cells, in AS. Finally, because valve calcification can be excellently evaluated by ex-vivo microcomputed tomography (micro-CT), we decided to investigate the associations between micro-CT findings and biological indices of calcification in severe AS.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

kardiochirurgia

Degree grantor:

Wydział Lekarski

Promoter:

Kapelak, Bogusław

Date issued:

2018

Identifier:

oai:dl.cm-uj.krakow.pl:4363

Call number:

ZB-130756

Language:

pol; eng

Access rights:

tylko w bibliotece

Subject and keywords:

aortic stenosis cardiac surgery fibrinolysis lymphocytes

Object collections:

Last modified:

Jun 26, 2023

In our library since:

Jul 24, 2020

Number of object content hits:

59

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4364

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Edition name Date
ZB-130756 Jun 26, 2023

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