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Title: Evaluation of selected indicators of the coagulation system and fibrinolysis and exercise capacity of patiensts with idiopathic atrerial and chronic thromboembolic pulmonary hypertension

Author:

Widlińska, Barbara

Date:

2019

Type:

Praca doktorska

Abstract:

PH is an increase in mPAP, leading to right ventricle failure and death. Pathogenesis includes contraction, vascular remodelling and in-situ thrombosis. The main symptom is dyspnoea. The study evaluated disorders in the coagulation system and fibrinolysis and its correlation with exercise capacity in patients with CTEPH and IPAH. The studies were taken during the first hospitalization. The mortality was also assessed during the study. There was a significantly impaired exercise capacity in both groups. CTEPH group had worse exercise capacity than IPAH. In Patients with CTEPH had a significantly higher level of fibrinogen compared to IPAH. However in both groups it was shown that with increasing impairment of exercise tolerance, damage to the right ventricle and liver function, the level of fibrinogen is lower. In both groups, there were no significant differences in the assessment of the other parameters of the coagulation system, i.e. INR, APTT, d-dimers, PLT, MPV and PDW. INR and d-dimer levels were elevated. It was found that the INR and mPAP values may be predictive factors of death, however, their sensitivity and specificity is not satisfactory.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Podolec, Piotr

Date issued:

2019

Identifier:

oai:dl.cm-uj.krakow.pl:4355

Call number:

ZB-131185

Language:

pol

Access rights:

tylko w bibliotece

Subject and keywords:

chronic thromboembolic pulmonary hypertension coagulation disorders fibrynolysis exercise tollerance in pulmonary hypertension idiopathic pulmonary arterial hypertension

Object collections:

Last modified:

Mar 13, 2023

In our library since:

Jun 30, 2020

Number of object content hits:

6

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4356

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Edition name Date
ZB-131185 Mar 13, 2023

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