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Title: Experimental management of urinary incontinence


Urinary incontinence has a strong impact on patients physical and emotional health as well as quality of life. However, currently used therapies are not free from limitations. It is of utmost importance to look for other treatment strategies. The aim of the first series of the study was to evaluate the impact of design specificities and structural differences of currently used mid-urethral slings. The aim of the second series was to characterize the mechanical properties of fibers extracted from previously used slings. The aim of the third series was to prospectively demonstrate pharmacological prevention of the neurogenic bladder secondary to spinal cord injury. In the first and second series, 30 Sprague-Dawley rats were implanted with two different type I monofilamentous, macroporous polypropylene meshes. The animals were sacrificed at set time intervals and the abdominal wall was harvested with mesh strips for histological evaluation as well as mechanical characterization. In the third series, 33 Sprague-Dawley rats were allocated to 6 groups. Spinal cord transection was performed in 30 animals and 24 of them were treated with fesoterodine. Cystometry was undertaken 6 weeks after transection. Structural differences and architectural features of polypropylene slings used in the experiment have had no impact on tissue integrity and inflammatory responses. Elastic modulus could be an appropriate factor to predict long-term implantation outcomes. Early administration of fesoterodine fumarate demonstrates short-term prevention of neurogenic bladder dysfunction secondary to spinal cord injury.

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Level of degree:

2 - studia doktoranckie

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Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.


Piotr Chłosta

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tylko w bibliotece

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Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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Last modified:

Mar 3, 2021

In our library since:

Jun 30, 2020

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Edition name Date
ZB-130604 Mar 3, 2021


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