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Influence of intraoperative nitric oxide inhalation on systemic inflammatory response during treatment of congenital heart disease in children

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Tytuł: Influence of intraoperative nitric oxide inhalation on systemic inflammatory response during treatment of congenital heart disease in children

Autor:

Stycuła, Wojciech

Data:

2018

Typ:

Praca doktorska

Abstrakt:

Surgical treatment of congenital heart disease demands application of cardiopulmonary – by-pass (CPB). It induces systemic inflammatory response influencing early and late results. In this work an influence of nitric oxide (NO) inhalation into the oxygenator during CPB on inflammatory response was assessed. Thirty patients were enrolled to the study and 14 randomly obtained NO inhalation. 9 samples of blood were taken preoperatively, intraoperatively and during postoperative period. All procedures were carried out using identical methodology and technique.Screening of 96 factors using Human Proteome Profiler Arrays was carried out. Based on it, 12 factors were selected for high sensitivity analysis with Miliplex Map Map Kit assays.Descriptive statistics and repeated measures ANOVA were used for statistical evaluation and p<0.05 was accepted as significant. Patients who received NO inhalation revealed inhibition of inflammatory (lower concentration of pro-inflammatory cytokines) and metabolic (lower insulin, glucose and pentraxin level) response, amplification of anti-inflammatory response (anti-inflammatory interleukins) lower organ and heart protection (lower lactate, CKMB and TnI levels). Patients with NO inhalation showed also shorter respiratory support time and lower catecholamine index.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

kardiochirurgia ; pediatria

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Kołcz, Jacek

Data wydania:

2017

Identyfikator:

oai:dl.cm-uj.krakow.pl:4347

Sygnatura:

ZB-130878

Język:

pol

Prawa dostępu:

nieograniczony

Temat i słowa kluczowe:

congenital heart disease systemic inflammatory response nitric oxide

Kolekcje, do których przypisany jest obiekt:

Data ostatniej modyfikacji:

26 cze 2023

Data dodania obiektu:

25 cze 2020

Liczba wyświetleń treści obiektu:

87

Liczba wyświetleń treści obiektu w formacie PDF

93

Wszystkie dostępne wersje tego obiektu:

http://dl.cm-uj.krakow.pl:8080/publication/4348

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Wyświetl opis w formacie OAI-PMH:

OAI-PMH

Nazwa wydania Data
ZB-130878 26 cze 2023

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Biblioteka Medyczna
ul. Medyczna 7
30-688 Kraków

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