Object

Title: Influence of intraoperative nitric oxide inhalation on systemic inflammatory response during treatment of congenital heart disease in children

Abstract:

Surgical treatment of congenital heart disease demands application of cardiopulmonary – by-pass (CPB). It induces systemic inflammatory response influencing early and late results. In this work an influence of nitric oxide (NO) inhalation into the oxygenator during CPB on inflammatory response was assessed. Thirty patients were enrolled to the study and 14 randomly obtained NO inhalation. 9 samples of blood were taken preoperatively, intraoperatively and during postoperative period. All procedures were carried out using identical methodology and technique.Screening of 96 factors using Human Proteome Profiler Arrays was carried out. Based on it, 12 factors were selected for high sensitivity analysis with Miliplex Map Map Kit assays.Descriptive statistics and repeated measures ANOVA were used for statistical evaluation and p<0.05 was accepted as significant. Patients who received NO inhalation revealed inhibition of inflammatory (lower concentration of pro-inflammatory cytokines) and metabolic (lower insulin, glucose and pentraxin level) response, amplification of anti-inflammatory response (anti-inflammatory interleukins) lower organ and heart protection (lower lactate, CKMB and TnI levels). Patients with NO inhalation showed also shorter respiratory support time and lower catecholamine index.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Jacek Kołcz

Date issued:

2017

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4347

Call number:

ZB-130878

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Jun 25, 2020

In our library since:

Jun 25, 2020

Number of object content hits:

7

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4348

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ZB-130878 Jun 25, 2020
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