Tytuł:

MRI - based in vivo assessment of endothelial function in murine models of cardiovascular diseases

Autor:

Bar, Anna

Temat i słowa kluczowe:

endothelial permeability ; endothelial dysfunction ; MRI ; murine models in vivo

Abstrakt:

Endothelial dysfunction accompanies development of many diseases, not exclusive to the cardiovascular system and has pathophysiological, prognostic and therapeutic significance. However, there are still no methods for fast and reliable evaluation of the endothelial phenotype in murine models in vivo, which are the basic model in preclinical studies in biomedicine.The aim of the studies was to apply the method of magnetic resonance imaging (MRI) of two main features of endothelial dysfunction in vivo, including impaired, endothelium-dependent vasodilatation and increased vascular permeability, for 1) assessment of the progression of endothelial dysfunction, 2) monitoring the efficacy of endothelium-targeted therapy and 3) to the study of the effects of the introduced genetic modification on the endothelial phenotype.PhD thesis consist of 3 published research papers. Papers included in PhD dissertation, based on a unique MRI method in vivo supplemented with biochemical measurements, bring new knowledge on the development of endothelial dysfunction in atherosclerosis, pharmacotherapeutic mechanisms of the endothelium, and the vascular effects of genetic modification of the endothelium. Therefore, the developed, multiparameter method of MR imaging of the endothelial phenotype in vivo, can be successfully used in preclinical studies using murine models of cardiovascular diseases.

Miejsce wydania:

Kraków

Stopień studiów:

2 - studia doktoranckie

Dyscyplina:

farmakologia ; choroby układu krążenia

Instytucja nadająca tytuł:

Wydział Lekarski

Promotor:

Chłopicki, Stefan

Data:

2019

Data wydania:

2019

Typ:

Praca doktorska

Sygnatura:

ZB-130615

Język:

pol; eng

Prawa dostępu:

nieograniczony