Advanced search ?

Object

MRI - based in vivo assessment of endothelial function in murine models of cardiovascular diseases

Download

Title: MRI - based in vivo assessment of endothelial function in murine models of cardiovascular diseases

Author:

Bar, Anna

Date:

2019

Type:

Praca doktorska

Abstract:

Endothelial dysfunction accompanies development of many diseases, not exclusive to the cardiovascular system and has pathophysiological, prognostic and therapeutic significance. However, there are still no methods for fast and reliable evaluation of the endothelial phenotype in murine models in vivo, which are the basic model in preclinical studies in biomedicine.The aim of the studies was to apply the method of magnetic resonance imaging (MRI) of two main features of endothelial dysfunction in vivo, including impaired, endothelium-dependent vasodilatation and increased vascular permeability, for 1) assessment of the progression of endothelial dysfunction, 2) monitoring the efficacy of endothelium-targeted therapy and 3) to the study of the effects of the introduced genetic modification on the endothelial phenotype.PhD thesis consist of 3 published research papers. Papers included in PhD dissertation, based on a unique MRI method in vivo supplemented with biochemical measurements, bring new knowledge on the development of endothelial dysfunction in atherosclerosis, pharmacotherapeutic mechanisms of the endothelium, and the vascular effects of genetic modification of the endothelium. Therefore, the developed, multiparameter method of MR imaging of the endothelial phenotype in vivo, can be successfully used in preclinical studies using murine models of cardiovascular diseases.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia ; choroby układu krążenia

Degree grantor:

Wydział Lekarski

Promoter:

Chłopicki, Stefan

Date issued:

2019

Identifier:

oai:dl.cm-uj.krakow.pl:4346

Call number:

ZB-130615

Language:

pol; eng

Access rights:

nieograniczony

Subject and keywords:

endothelial permeability endothelial dysfunction MRI murine models in vivo

Object collections:

Last modified:

Dec 18, 2024

In our library since:

Jun 25, 2020

Number of object content hits:

104

Number of object content views in PDF format

0

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4347

Show description in RDF format:

RDF

Show description in OAI-PMH format:

OAI-PMH

Edition name Date
ZB-130615 Dec 18, 2024

Objects

Similar

MRI - based in vivo assessment of endothelial function in murine models of cardiovascular diseases

Bar, Anna

2019
Praca doktorska

Assesment of clinical value of imagine and functinal techniques in diagnostic of partial epilepsy in childhood

Zając, Anna

2006
Praca doktorska

Effect of using different computer programs to analyze BOLD onplanning neurosurgical procedures in patients with brain tumor

Kozub, Justyna

2015
Praca doktorska

Assessment of the cardiac function in mice model of dilated cardiomyopathy (Tgαq*44) and atherosclerosis (apoE/LDLR-/-) by in vivo MRI

Tyrankiewicz, Urszula

2013
Praca doktorska

Some vascular effects of hormones contributing to the regulation of appetite

Kawczyńska-Dróżdż, Agnieszka

2009
Praca doktorska

Selected aspects of endothelial dysfunction in patients with type 2 diabetes

Waluś-Miarka, Małgorzata

2008
Praca doktorska

Prognostic value of endothelial function noninvasive assessment in patients with acute coronary syndrome nonobstructive coronary angiography

Depukat, Rafał

2013
Praca doktorska

Influence of autoimmunity on endothelial dysfunction and atherosclerosis development in young patients with coronary artery disease and in systemic lupus erythematosus patients

Mazurek, Adam

2020
Praca doktorska
More
×

Citation

Citation style:

Contact details

Address

Medical Library
Medyczna 7
30-688 Krakow

Phone

12 658 72 56
517 385 669

E-Mail

Collecting and Elaboration Department
cyfrowabm@cm-uj.krakow.pl

Visit us!

This page uses 'cookies'. More information