Object

Title: MRI - based in vivo assessment of endothelial function in murine models of cardiovascular diseases

Abstract:

Endothelial dysfunction accompanies development of many diseases, not exclusive to the cardiovascular system and has pathophysiological, prognostic and therapeutic significance. However, there are still no methods for fast and reliable evaluation of the endothelial phenotype in murine models in vivo, which are the basic model in preclinical studies in biomedicine.The aim of the studies was to apply the method of magnetic resonance imaging (MRI) of two main features of endothelial dysfunction in vivo, including impaired, endothelium-dependent vasodilatation and increased vascular permeability, for 1) assessment of the progression of endothelial dysfunction, 2) monitoring the efficacy of endothelium-targeted therapy and 3) to the study of the effects of the introduced genetic modification on the endothelial phenotype.PhD thesis consist of 3 published research papers. Papers included in PhD dissertation, based on a unique MRI method in vivo supplemented with biochemical measurements, bring new knowledge on the development of endothelial dysfunction in atherosclerosis, pharmacotherapeutic mechanisms of the endothelium, and the vascular effects of genetic modification of the endothelium. Therefore, the developed, multiparameter method of MR imaging of the endothelial phenotype in vivo, can be successfully used in preclinical studies using murine models of cardiovascular diseases.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

farmakologia ; choroby układu krążenia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Stefan Chłopicki

Date issued:

2019

Format:

application/pdf

Identifier:

oai:dl.cm-uj.krakow.pl:4346

Call number:

ZB-130615

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

Object collections:

Last modified:

Mar 11, 2021

In our library since:

Jun 25, 2020

Number of object content hits:

10

All available object's versions:

http://dl.cm-uj.krakow.pl:8080/publication/4347

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ZB-130615 Mar 11, 2021
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