Title:

The evaluation of tumor microenvironment in distinct breast cancer molecular subtypes

Author:

Glajcar, Anna

Subject:

breast cancer ; microenvironment ; lymphocytes ; mast cells

Abstract:

The study aimed to investigate the infiltrate of immune cells (mast cells, T and B lymphocytes, cytotoxic, regulatory and T helper type 2 cells) in primary invasive breast cancer tissue excisions. Densities of respective immune cells were evaluated as the numbers of positively immunostained cells using light microscope and referred to breast cancer molecular subtype and other prognostic indicators. We found differences in densities of the immune cells that point to relationship between mast cells and clinically less aggressive breast cancer molecular subtypes as well as more favourable prognostic factors. More dense infiltrate of lymphoid, cytotoxic and regulatory cells was observed in clinically more aggressive subtypes of cancer and in tumors characterized by adverse prognostic indicators. The obtained results suggest a distinct role of immune cells in cancer progression, depending on breast cancer molecular subtypes and location of the cells in tumor tissue.

Place of publishing:

Kraków

Level of degree:

2 - studia doktoranckie

Degree discipline:

onkologia ; ginekologia

Degree grantor:

Uniwersytet Jagielloński. Collegium Medicum. Wydział Lekarski.

Promoter:

Krzysztof Okoń ; Joanna Szpor

Date:

2019

Date issued:

2019

Type:

Praca doktorska

Format:

application/pdf

Call number:

ZB-131177

Access rights:

nieograniczony

Location of original object:

Biblioteka Medyczna Uniwersytetu Jagiellońskiego- Collegium Medicum

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