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Pizoń, Tomasz
2019
Praca doktorska
The effectiveness of treatment of hypertension is low. The guidelines can be supplemented with "pathophysiological approach" to an individualized therapy.The objectives:-examination of the relationship between plasma renin activity (PRA), aldosterone and asymptomatic organ damage (AOD)-exploring the effect of antihypertensive treatment, consistent with Laragh and Alderman hypothesis, on blood pressure and AOD-evaluation of clinical and biochemical discrepancies among patients from low-renin and high-renin groups with particular reference to the values of serum lipidsOperating range: a planned prospective trial that included a total of 95-122 patients with first or second-degree hypertension.Conclusions:-the study of the effect of the renin-angiotensin-aldosterone system (RAAS) on the occurrence of AOD should include the relationship between the concentration of aldosterone and renin-PRA as the only indicator has no predictive value for the occurrence of AOD, on the other hand an aldosterone-to-renin ratio (ARR) does have it-the choice of antihypertensive drug based on PRA does not determine either the magnitude of the blood pressure reduction nor thesignificance of the AOD regression-patients with high-renin hypertension are characterized by higher serum total cholesterol and LDL-cholesterol, but the relationship between LDL-cholesterol and PRA is only in the low-renin group.
Kraków
2 - studia doktoranckie
choroby układu krążenia
Wydział Lekarski
Rajzer, Marek
2018
oai:dl.cm-uj.krakow.pl:4344
ZB-130875
pol; eng
tylko w bibliotece
26 cze 2023
23 cze 2020
29
0
http://dl.cm-uj.krakow.pl:8080/publication/4345
RDF
OAI-PMH
Woźniak, Mirosław
Kameczura, Tomasz
Popiołek, Lech
Kocowska, Maryla
Cwynar, Marcin
Dzieża-Grudnik, Anna
Widlińska, Barbara
Styl cytowania: chicago-author-date iso690-author-date
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